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In Zimbabwe, as in many parts of sub-Saharan Africa, home-based care (HBC) plays a vital role in the response to HIV as overwhelmed public health and welfare systems fail to cope with the demands of the epidemic. HBC organizations have evolved and grown relatively organically throughout Zimbabwe in response to the epidemic, supporting and directing the activities of caregivers as the epidemic has dictated. To understand more about the development of HBC in Zimbabwe and its future potential, Irish Aid engaged Health & Development Networks (HDN) and the Southern Africa HIV and AIDS Information Dissemination Service (SAfAIDS) to assess and document lessons from HBC interventions. This document details a project designed to contribute to better understanding and evidence-based decision-making in the implementation of HBC interventions in Zimbabwe and beyond.